Multimodal treatment concept based on focused shock wave therapy (ESWT) with PiezoWave² technology
Extracorporeal focused shock wave therapy (ESWT) delivered through PiezoWave² technology is a non-invasive modality that stimulates and modulates neurovascular, metabolic, and regenerative processes within the treated tissues. Its effects are based on mechanotransduction, triggering local and systemic biological responses with regenerative and analgesic potential.
Described biological mechanisms
Deactivation of myofascial trigger points in the pelvic floor and adjacent structures.
Release of nitric oxide (NO), leading to:
Vasodilation and increased microcirculation.
Metabolic stimulation and angiogenesis.
Anti-inflammatory effects.
Enhanced local perfusion and modulation of pro-inflammatory mediators.
Induction of growth factors such as:
TGF-β1 (Transforming Growth Factor Beta 1).
VEGF (Vascular Endothelial Growth Factor).
Stimulation of mesenchymal stem cell migration, supporting tissue repair.
Indirect antibacterial effects described in certain experimental models.
Activation of fibroblasts and collagen synthesis, contributing to structural regeneration.
Release of “Substance P” and modulation of nociceptors, associated with analgesic effects.
Stimulation of lubricin production, a protein that reduces friction and improves connective tissue elasticity.
The application is focused and depth-controlled (from 0 to 172 mm depending on the transducer), without the need for probes or intravaginal applicators, allowing for a completely extracorporeal approach.
Main clinical indications
Urology
Chronic prostatic pain / non-bacterial prostatitis.
Bladder pain syndrome / interstitial cystitis.
Urethral or scrotal pain.
Vasculogenic erectile dysfunction (ED).
Induratio penis plastica (IPP / Peyronie’s disease).
Chronic pelvic pain syndrome (CPPS).
Gynecology
Vaginal or vulvar pain (vulvodynia, vestibulitis).
Clitoral or ovarian pain.
Postpartum pelvic pain or pain associated with surgical scars.
Chronic pelvic pain syndrome (CPPS).
Gynecological aesthetic applications.
Proctological and neurological syndromes
Anorectal pain and levator ani syndrome.
Pudendal neuralgia.
Coccydynia (tailbone pain).
Therapeutic objectives
Restore endothelial function and promote neovascularization in the corpora cavernosa.
Reduce calcifications and fibrosis of the tunica albuginea through mechanical and biostimulatory effects.
Improve vaginal lubrication and elasticity, as well as associated urinary alterations.
Reach and relax deep pelvic floor muscles, deactivate trigger points, and improve prostatic perfusion.
Promote muscular and tendinous neovascularization, reducing stiffness and contractures.
Stimulate metabolic and proliferative responses, modulating fibrosis and improving tissue rheological properties.
Support tissue regeneration and normalization of neuromuscular transmission (e.g., partial blockade of acetylcholine receptors).
Provide functional and aesthetic improvements in the genital and pelvic floor area.
Available clinical studies describe significant pain reduction (VAS), functional improvements, and enhanced subjective quality of life in patients treated with PiezoWave² focused shock waves, with no relevant adverse effects reported.